Project Description
In this project you will learn to synthesize and modify upconverting nanoparticles (UCNPs) for protein conjugation. You will analyze different methods of chemically conjugating photoreactive proteins to the UCNPs. Once conjugated, you will explore the distribution of photoreactive fusion protein-UCNP conjugates in in vitro cell models including tumor spheroids. At the end of your work, you will present results to the group in the form of a poster or PowerPoint. You will be a part of an interdisciplinary group with individuals working in diverse areas from biomaterials to protein engineering.
Special Requirements
Students should have taken general chemistry. Basic knowledge of cell biology and biochemistry would be helpful. Student should be able to work for longer hours (~6-8 hours) once a week due to the nature of UCNP synthesis.
Contact
- Jennifer Cha (facutly)
- Shane Curry (graduate student)