Publications

The transcatheter aortic valve replacement (TAVR) procedure has emerged as a minimally invasive treatment for patients with aortic valve stenosis (AVS). However, alterations in serum factor composition and biological activity after TAVR remain unknown. Here, we quantified the systemic inflammatory effects of the TAVR procedure and hypothesized that alterations in...

Mycobacterium vaccae (NCTC 11659) is an environmental saprophytic bacterium with anti-inflammatory, immunoregulatory, and stress resilience properties. Previous studies have shown that whole, heat-killed preparations of M. vaccae prevent allergic airway inflammation in a murine model of allergic asthma. Recent studies also demonstrate that immunization with M. vaccae prevents stress-induced exaggeration...

Hydrogen deuterium exchange mass spectrometry (HDX-MS) is a powerful biophysical technique being increasingly applied to a wide variety of problems. As the HDX-MS community continues to grow, adoption of best practices in data collection, analysis, presentation and interpretation will greatly enhance the accessibility of this technique to nonspecialists. Here we...

Allison C. Morgan, Dimitrios J. Economou, Samuel F. Way and Aaron Clauset are all scholars in the department of computer science at the University of Colorado at Boulder. They have just published an important new article about how ideas spread within the academy. I asked them a series of questions...

The natural world has had billions of years of evolution to perfect systems, creating elegant solutions to tricky problems. CU Boulder Assistant Professor Orit Peleg ’s work hopes to illuminate and explore those solutions with the long-term goal of applying the answers she finds to the materials we interact with...

Since the end of World War II, few violent conflicts have erupted between major powers. Scholars have come to call this 73-year period “the long peace.” But is this stretch of relative calm truly unusual in modern human history – and evidence that peace-keeping efforts are working? Or is it...

More than 23.5 million Americans suffer from autoimmune diseases like rheumatoid arthritis, scleroderma and lupus, in which an overzealous immune response leads to pain, inflammation, skin disorders and other chronic health problems. The conditions are so common that three of the top five selling drugs in the United States aim...

Just as flu season swings into full gear, researchers from the University of Colorado Boulder and University of Texas at Austin have uncovered a previously unknown mechanism by which the human immune system tries to battle the influenza A virus. The discovery sheds new light on how the virus —...

Amidst the vast and varied ecosystem of modern science, the emerging interdisciplinary field known as the “science of science” is exploring a difficult, but provocative, question: In the age of data science, are future discoveries now predictable? In an article published this week in the journal Science , CU Boulder...

A deep look inside the live cells reveals a key cancer process Telomerase, a powerful enzyme found at the ends of chromosomes, can keep humans healthy, or promote cancer growth. Researchers at the University of Colorado in Boulder used a process called single-molecule imaging to look into the complicated processes...