Andrew Grotzinger portrait
Assistant Professor
Psychology & Neuroscience • Institute for Behavioral Genetics
Andrew.Grotzinger@colorado.edu

Research Interests:

Multivariate genomic methods development and their application to psychiatric and cognitive traits.

Active Grants:

  • NIA RF1 AG073593 (Tucker-Drob) 8/15/2021 – 7/31/2024 Large-scale Genomic Analysis of Aging-related Cognitive Change Prior to Dementia Onset. Role: Co-Investigator
  • NIMH R01 MH120219 (Nivard & Tucker-Drob) 07/17/2020-04/30/2025 Dissecting the Multivariate Genetic Architecture of Psychiatric Diseases. Role: Co-Investigator
  • Tommy Fuss Foundation Private Grant (Smoller) 1/1/2022 - 12/31/23. Mapping Genomics to Brain Structure, Psychiatric Disorders, and Therapeutic Targets. Role: Subcontract PI
  • HD027802 (PI: Willcutt), 7/1/23-6/30/28, "Differential Diagnosis in Learning Disabilities", Role: Co-Investigator on Data Core

Additional Resources:

Current CV

GenomicSEM on github

Current lab

Sophia Breunig portrait
Sophie Breunig
Predoctoral Trainee
Institute for Behavioral Genetics
Isabelle Foote portrait
Isabelle Foote
Postdoctoral Associate
Institute for Behavioral Genetics
Jeremy Lawrence portrait
Jeremy Lawrence
Predoctoral Trainee
Institute for Behavioral Genetics
Lukas Schafer portrait
Lukas Schaffer
Predoctoral Trainee
Psychology & Neuroscience

Publications

Google Scholar

Genomic SEM applied to explore etiological divergences in bipolar subtypes

CU Boulder Authors: Grotzinger, Andrew David
All Authors: Lawrence JM; Breunig S; Foote IF; Tallis CB; Grotzinger AD
Published in: Psychological Medicine
Publication Date: 2024-04-01
Type: Journal Article

Beyond the factor indeterminacy problem using genome-wide association data

CU Boulder Authors: Grotzinger, Andrew David
All Authors: Clapp Sullivan ML; Schwaba T; Harden KP; Grotzinger AD; Nivard MG; Tucker-Drob EM
Published in: Nature Human Behaviour
Publication Date: 2024-01-15
Type: Journal Article

Multivariate genomic architecture of cortical thickness and surface area at multiple levels of analysis

CU Boulder Authors: Grotzinger, Andrew David
All Authors: Grotzinger AD; Mallard TT; Liu Z; Seidlitz J; Ge T; Smoller JW
Published in: Nature Communications
Publication Date: 2023-12-07
Type: Journal Article

GENETIC OVERLAP BETWEEN CHRONIC PAIN, SUBSTANCE USE DISORDERS, AND NUCLEUS ACCUMBENS VOLUME

CU Boulder Authors: Friedman, Naomi P; Grotzinger, Andrew David
All Authors: Rader L; Zorina-Lichtenwalter K; Grotzinger AD; Friedman NP
Published in: European Neuropsychopharmacology
Publication Date: 2023-10-10
Type: Conference Proceeding

Genetic risk shared across 24 chronic pain conditions: identification and characterization with genomic structural equation modeling

CU Boulder Authors: Grotzinger, Andrew David; Keller, Matthew C; Friedman, Naomi P; Ceko, Marta
All Authors:
Zorina-Lichtenwalter K; Bango CI; Van Oudenhove L; Ceko M; Lindquist MA; Grotzinger AD; Keller MC; Friedman NP; Wager TD...
  • Zorina-Lichtenwalter K
  • Bango CI
  • Van Oudenhove L
  • Ceko M
  • Lindquist MA
  • Grotzinger AD
  • Keller MC
  • Friedman NP
  • Wager TD
Published in: Pain
Publication Date: 2023-10-01
Type: Journal Article

Genetic insights into human cortical organization and development through genome-wide analyses of 2,347 neuroimaging phenotypes

CU Boulder Authors: Grotzinger, Andrew David
All Authors:
Warrier V; Stauffer E-M; Huang QQ; Wigdor EM; Slob EAW; Seidlitz J; Ronan L; Valk SL; Mallard TT; Grotzinger AD...
  • Warrier V
  • Stauffer E-M
  • Huang QQ
  • Wigdor EM
  • Slob EAW
  • Seidlitz J
  • Ronan L
  • Valk SL
  • Mallard TT
  • Grotzinger AD
Published in: Nature Genetics
Publication Date: 2023-09-01
Type: Journal Article

Genetic associations between alcohol phenotypes and life satisfaction: a genomic structural equation modelling approach

CU Boulder Authors: Grotzinger, Andrew David
All Authors:
Bountress KE; Cusack SE; Hawn SE; Grotzinger A; Bustamante D; Kirkpatrick RM; Edenberg HJ; Amstadter AB...
  • Bountress KE
  • Cusack SE
  • Hawn SE
  • Grotzinger A
  • Bustamante D
  • Kirkpatrick RM
  • Edenberg HJ
  • Amstadter AB
Published in: Scientific Reports
Publication Date: 2023-08-18
Type: Journal Article

Transcriptome-Wide Structural Equation Modeling of 13 Major Psychiatric Disorders for Cross-Disorder Risk and Drug Repurposing

CU Boulder Authors: Grotzinger, Andrew David
All Authors: Grotzinger AD; Singh K; Miller-Fleming TW; Lam M; Mallard TT; Chen Y; Liu Z; Ge T; Smoller JW
Published in: JAMA Psychiatry
Publication Date: 2023-08-01
Type: Journal Article

A Multivariate Genome-wide Association Study of the Shared Genetic Architecture Among Modifiable Risk Factors for Dementia.

CU Boulder Authors: Grotzinger, Andrew David
All Authors: Foote I; Grotzinger A
Publication Date: 2023-07-28
Type: Conference Proceeding

Genomic SEM Applied to Explore Etiological Divergences in Bipolar Subtypes.

CU Boulder Authors: Grotzinger, Andrew David
All Authors: Lawrence J; Breunig S; Foote I; Grotzinger A
Publication Date: 2023-06-23
Type: Conference Proceeding

Elucidating the Multivariate Genetic Architecture of Frailty Using Genomic Structural Equation Modelling.

CU Boulder Authors: Grotzinger, Andrew David
All Authors: Foote I; Rockwood K; Grotzinger A
Publication Date: 2023-06-23
Type: Conference Proceeding

Examining Differences in the Genetic and Functional Architecture of ADHD Diagnosed in Childhood or Adulthood

CU Boulder Authors: Grotzinger, Andrew David
All Authors: Breunig S; Lawrence J; Grotzinger A
Publication Date: 2023-06-22
Type: Conference Proceeding

Transcriptome-wide gene-gene interaction associations elucidate pathways and functional enrichment of complex traits

CU Boulder Authors: Hoeffer, Charles Albert; Stitzel, Jerry A; Evans, Luke M.; Grotzinger, Andrew David; Ehringer, Marissa A
All Authors: Evans LM; Arehart CH; Grotzinger AD; Mize TJ; Brasher MS; Stitzel JA; Ehringer MA; Hoeffer CA
Published in: PLoS Genetics
Publication Date: 2023-05-01
Type: Journal Article

EXAMINING THE SHARED ETIOLOGY OF PSYCHOPATHOLOGY WITH GENOME-WIDE ASSOCIATION STUDIES

CU Boulder Authors: Grotzinger, Andrew David
All Authors: Mallard TT; Grotzinger AD; Smoller JW
Published in: Physiological Reviews
Publication Date: 2023-04-01
Type: Journal Article

Multivariate genome-wide association meta-analysis of over 1 million subjects identifies loci underlying multiple substance use disorders

CU Boulder Authors: Grotzinger, Andrew David; Boardman, Jason D
All Authors:
Hatoum AS; Colbert SMC; Johnson EC; Huggett SB; Deak JD; Pathak GA; Jennings MV; Paul SE; Karcher NR; Hansen I...
  • Hatoum AS
  • Colbert SMC
  • Johnson EC
  • Huggett SB
  • Deak JD
  • Pathak GA
  • Jennings MV
  • Paul SE
  • Karcher NR
  • Hansen I
Publication Date: 2023-03-22
Type: Journal Article

Pervasive Downward Bias in Estimates of Liability-Scale Heritability in Genome-wide Association Study Meta-analysis: A Simple Solution

CU Boulder Authors: Grotzinger, Andrew David
All Authors: Grotzinger AD; de la Fuente J; Prive F; Nivard MG; Tucker-Drob EM
Published in: Biological Psychiatry
Publication Date: 2023-01-01
Type: Journal Article

Potential bias in genetic correlations Mating patterns across two traits can inflate estimates of genetic overlap

CU Boulder Authors: Grotzinger, Andrew David; Keller, Matthew C
All Authors: Grotzinger AD; Keller MC
Published in: Science
Publication Date: 2022-11-18
Type: Journal Article

A Mixed-Methods Approach to Refining and Measuring the Construct of Positive Risk-Taking in Adolescence

CU Boulder Authors: Grotzinger, Andrew David
All Authors:
Patterson MW; Pivnick L; Mann FD; Grotzinger AD; Monahan KC; Steinberg LD; Oosterhoff B; Tackett JL; Tucker-Drob EM; Har...
  • Patterson MW
  • Pivnick L
  • Mann FD
  • Grotzinger AD
  • Monahan KC
  • Steinberg LD
  • Oosterhoff B
  • Tackett JL
  • Tucker-Drob EM
  • Harden KP
Published in: Journal of Research on Adolescence
Publication Date: 2022-11-10
Type: Journal Article

Transcriptome-wide and stratified genomic structural equation modeling identify neurobiological pathways shared across diverse cognitive traits

CU Boulder Authors: Grotzinger, Andrew David
All Authors: Grotzinger AD; de la Fuente J; Davies G; Nivard MG; Tucker-Drob EM
Published in: Nature Communications
Publication Date: 2022-10-21
Type: Journal Article

An In-Laboratory Stressor Reveals Unique Genetic Variation in Child Cortisol Output

CU Boulder Authors: Grotzinger, Andrew David
All Authors:
Raffington L; Malanchini M; Grotzinger AD; Madole JW; Engelhardt LE; Sabhlok A; Youn C; Patterson MW; Harden KP; Tucker-...
  • Raffington L
  • Malanchini M
  • Grotzinger AD
  • Madole JW
  • Engelhardt LE
  • Sabhlok A
  • Youn C
  • Patterson MW
  • Harden KP
  • Tucker-Drob EM
Published in: Developmental Psychology
Publication Date: 2022-10-01
Type: Journal Article

A Multi-method Approach to Psychiatric Genomics Consortium Cross-Disorder Analyses.

CU Boulder Authors: Grotzinger, Andrew David
All Authors: Grotzinger A; Smoller J; Frei O; Werme J; de Leeuw C; Peyrot W
Publication Date: 2022-09-13
Type: Conference Proceeding

Identification and characterization of genetic risk shared across 24 chronic pain conditions in the UK Biobank

CU Boulder Authors: Keller, Matthew C; Grotzinger, Andrew David; Friedman, Naomi P
All Authors:
Zorina-Lichtenwalter K; Bango CI; Van Oudenhove L; Čeko M; Lindquist MA; Grotzinger AD; Keller MC; Friedman NP; Wager T...
  • Zorina-Lichtenwalter K
  • Bango CI
  • Van Oudenhove L
  • Čeko M
  • Lindquist MA
  • Grotzinger AD
  • Keller MC
  • Friedman NP
  • Wager TD
Publication Date: 2022-06-30
Type: Journal Article

Developing Genomic SEM to Identify Sex Differences in the Multivariate Genetic Architecture of Psychiatric Disorders

CU Boulder Authors: Grotzinger, Andrew David
All Authors: Schwaba T; Grotzinger AD; Nivard MG; Davis LK; Tucker-Drob EM
Published in: Behavior Genetics: an international journal devoted to research in the inheritance of behavior in animals and man
Publication Date: 2022-06-22
Type: Conference Proceeding

Using Genomic Structural Equation Modeling to Test the Validity of Latent Factor Models

CU Boulder Authors: Grotzinger, Andrew David
All Authors: Clapp ML; Grotzinger AD; Tucker-Drob EM
Published in: Behavior Genetics: an international journal devoted to research in the inheritance of behavior in animals and man
Publication Date: 2022-06-22
Type: Conference Proceeding

Multivariate Modeling of Direct and Proxy GWAS Indicates Substantial Common Variant Heritability of Alzheimer's Disease

CU Boulder Authors: Grotzinger, Andrew David
All Authors: de la Fuente J; Grotzinger AD; Marioni RE; Nivard MG; Tucker-Drob EM
Published in: Behavior Genetics: an international journal devoted to research in the inheritance of behavior in animals and man
Publication Date: 2022-06-22
Type: Conference Proceeding

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