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Structure and Mechanism of a Cyclic Trinucleotide-Activated Bacterial Endonuclease Mediating Bacteriophage Immunity.
Lau RK, Ye Q, Birkholz EA, Berg KR, Patel L, Mathews IT, Watrous JD, Ego K, Whiteley AT, Lowey B, Mekalanos JJ, Kranzusch PJ, Jain M, Pogliano J, Corbett KD.
Mol Cell. 2020 Jan 6. pii: S1097-2765(19)30923-2. doi: 10.1016/j.molcel.2019.12.010. [Epub ahead of print]
PMID:31932164

 

Analysis of human cGAS activity and structure.
Zhou W, Whiteley AT, Kranzusch PJ.
Methods Enzymol. 2019;625:13-40. doi: 10.1016/bs.mie.2019.04.012. Epub 2019 May 2.
PMID:31455523

 

Bacterial cGAS-like enzymes synthesize diverse nucleotide signals.
Whiteley AT, Eaglesham JB, de Oliveira Mann CC, Morehouse BR, Lowey B, Nieminen EA, Danilchanka O, King DS, Lee ASY, Mekalanos JJ, Kranzusch PJ.
Nature. 2019 Mar;567(7747):194-199. doi: 10.1038/s41586-019-0953-5. Epub 2019 Feb 20.
PMID:30787435. Free PMC Article

 

Structure of the Human cGAS-DNA Complex Reveals Enhanced Control of Immune Surveillance.
Zhou W, Whiteley AT, de Oliveira Mann CC, Morehouse BR, Nowak RP, Fischer ES, Gray NS, Mekalanos JJ, Kranzusch PJ.
Cell. 2018 Jul 12;174(2):300-311.e11. doi: 10.1016/j.cell.2018.06.026.
PMID:30007416. Free PMC Article

 

Listeria monocytogenes triggers noncanonical autophagy upon phagocytosis, but avoids subsequent growth-restricting xenophagy.

Mitchell G, Cheng MI, Chen C, Nguyen BN, Whiteley AT, Kianian S, Cox JS, Green DR, McDonald KL, Portnoy DA.

Proc Natl Acad Sci U S A. 2018 Jan 9;115(2):E210-E217. doi: 10.1073/pnas.1716055115. Epub 2017 Dec 26.

PMID: 29279409 

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Activation of the Listeria monocytogenes Virulence Program by a Reducing Environment.

Portman JL, Dubensky SB, Peterson BN, Whiteley AT, Portnoy DA.

mBio. 2017 Oct 17;8(5). pii: e01595-17. doi: 10.1128/mBio.01595-17.

PMID: 29042499 

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A Redox-Responsive Transcription Factor Is Critical for Pathogenesis and Aerobic Growth of Listeria monocytogenes.

Whiteley AT, Ruhland BR, Edrozo MB, Reniere ML.

Infect Immun. 2017 Apr 21;85(5). pii: e00978-16. doi: 10.1128/IAI.00978-16. Print 2017 May.

PMID: 28193635 

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c-di-AMP modulates Listeria monocytogenes central metabolism to regulate growth, antibiotic resistance and osmoregulation.

Whiteley AT, Garelis NE, Peterson BN, Choi PH, Tong L, Woodward JJ, Portnoy DA.

Mol Microbiol. 2017 Apr;104(2):212-233. doi: 10.1111/mmi.13622. Epub 2017 Mar 8.

PMID: 28097715 

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An In Vivo Selection Identifies Listeria monocytogenes Genes Required to Sense the Intracellular Environment and Activate Virulence Factor Expression.

Reniere ML, Whiteley AT, Portnoy DA.

PLoS Pathog. 2016 Jul 14;12(7):e1005741. doi: 10.1371/journal.ppat.1005741. eCollection 2016 Jul.

PMID: 27414028 

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The PAMP c-di-AMP Is Essential for Listeria monocytogenes Growth in Rich but Not Minimal Media due to a Toxic Increase in (p)ppGpp. [corrected].

Whiteley AT, Pollock AJ, Portnoy DA.

Cell Host Microbe. 2015 Jun 10;17(6):788-98. doi: 10.1016/j.chom.2015.05.006. Epub 2015 May 28. Erratum in: Cell Host Microbe. 2015 Jul 8;18(1):132. 

PMID: 26028365 

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RNA-Based Fluorescent Biosensors for Live Cell Imaging of Second Messenger Cyclic di-AMP.

Kellenberger CA, Chen C, Whiteley AT, Portnoy DA, Hammond MC.

J Am Chem Soc. 2015 May 27;137(20):6432-5. doi: 10.1021/jacs.5b00275. Epub 2015 May 15.

PMID: 25965978 

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Glutathione activates virulence gene expression of an intracellular pathogen.

Reniere ML, Whiteley AT, Hamilton KL, John SM, Lauer P, Brennan RG, Portnoy DA.

Nature. 2015 Jan 8;517(7533):170-3. doi: 10.1038/nature14029.

PMID: 25567281 

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Cyclic di-AMP is critical for Listeria monocytogenes growth, cell wall homeostasis, and establishment of infection.

Witte CE, Whiteley AT, Burke TP, Sauer JD, Portnoy DA, Woodward JJ.

mBio. 2013 May 28;4(3):e00282-13. doi: 10.1128/mBio.00282-13.

PMID: 23716572 

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