The connection between presenillin-1, calcium regulation, and Alzheimer’s disease may provide the key to understanding the long-observed, but poorly understood, link between Alzheimer’s disease and Calcium (II) dysregulation. In this study, Janet examined seven familial Alzheimer’s causing mutations in presenillin-1 to define how they influence ER calcium levels and dynamics. Ultimately, results indicate that mutations in presenillin-1 can alter the balance of calcium in cells and have the potential to influence the nature of calcium signals.
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