Stem Cells News

MARCH 2025

ESC and iSPC

Neural

Cell Therapy

Organoids

FEBRUARY 2025:

ESC and iSPC

Neural

Cell Therapy

Organoids

 

JANUARY 2025:

ESC and iSPC

Neural

Cell Therapy

Organoids

 

DECEMBER 2024:

ESC and iSPC

Neural

Cell Therapy

Organoids

November 2024:

ESC and iSPC

Neural

Cell Therapy

Organoids

October 2024

ESC and iPSC

Neural

Cell Therapy

Organoid

 

September 2024

ESC and iPSC

Neural

Cell Therapy

Organoid

 

August 2024

ESC and iPSC

Neural

Cell Therapy

Organoid

 

July 2024

ESC and iPSC:

Neural

Cell Therapy

Organoid

June 2024

ESC and iPSC

Neural

Cell Therapy

Organoid

May 2024

ESC and IPSC 

 

Neural 

 

Cell Therapy 

 

Organoid 

 

April 2024

ESC and IPSC 

 

Neural 

 

Cell Therapy 

 

Organoid 

 

March 2024

ESC and IPSC 

 

Neural 

 

Cell Therapy 

 

Organoid 

 

February 2024

ESC and IPSC 

 

Neural 

 

Cell Therapy 

 

Organoid 

 

January 2024

ESC &iPSC

  • Hallmarks of Stemness in Mammalian Tissues https://www.stemcellsciencenews.com/newsletter/219117/ (Cell Stem Cell)
  • FOXO1-Mediated Lipid Metabolism Maintains Mammalian Embryos in Dormancy https://www.stemcellsciencenews.com/newsletter/219186/ (Nature Cell Biology)
  • DNA Methylation Restricts Coordinated Germline and Neural Fates in Embryonic Stem Cell Differentiation https://www.stemcellsciencenews.com/newsletter/219185/ (Nature Structural & Molecular Biology)
  • XIST Directly Regulates X-Linked and Autosomal Genes in Naive Human Pluripotent Cells https://www.stemcellsciencenews.com/newsletter/219250/ (Cell)
  • Mitotic Bookmarking Redundancy by Nuclear Receptors in Pluripotent Cells https://www.stemcellsciencenews.com/newsletter/219390/ (Nature Structural & Molecular Biology)
  • ROR2 Expression Predicts Human-Induced Pluripotent Stem Cell Differentiation into Neural Stem/Progenitor Cells and GABAergic Neurons https://www.stemcellsciencenews.com/newsletter/219597/ (Scientific Reports)
  • Generation of Three Isogenic Human Induced Pluripotent Stem Cell Lines from Normal Neonate Skin Fibroblasts https://www.stemcellsciencenews.com/newsletter/219595/ (Stem Cell Research)
  • Incomplete Reprogramming of DNA Replication Timing in Induced Pluripotent Stem Cells https://www.stemcellsciencenews.com/newsletter/219593/ (Cell Reports)
  • Cloned Rhesus Monkey Lives to Adulthood for First Time https://www.stemcellsciencenews.com/newsletter/219801/ (Nature News)
  • Lineage Regulators TFAP2C and NR5A2 Function as Bipotency Activators in Totipotent Embryos https://www.stemcellsciencenews.com/newsletter/219996/ (Nature Structural & Molecular Biology)
  • ZFP281 Controls Transcriptional and Epigenetic Changes Promoting Mouse Pluripotent State Transitions via DNMT3 and TET1 https://www.stemcellsciencenews.com/newsletter/220028/ (Developmental Cell)
  • Telomere Dynamics in Human Pluripotent Stem Cells https://www.stemcellsciencenews.com/newsletter/220209/ (Cell Cycle)
  • The Impact of Induced Pluripotent Stem Cells in Animal Conservation https://www.stemcellsciencenews.com/newsletter/220205/ (Veterinary Research Communications)

Neural

  • SpaceX Returns Vital Life Science Research Sponsored by the ISS National Lab https://www.stemcellsciencenews.com/newsletter/219008/ (ISS National Lab)
  • Shigella Virulence Protein VirG Is a Broadly Protective Antigen and Vaccine Candidate https://www.stemcellsciencenews.com/newsletter/219023/ (NPJ Vaccines)
  • Combined Small-Molecule Treatment Accelerates Maturation of Human Pluripotent Stem Cell-Derived Neurons https://www.stemcellsciencenews.com/newsletter/219022/ (Nature Biotechnology)
  • Human Cerebellar Organoids with Functional Purkinje Cells https://www.stemcellsciencenews.com/newsletter/219114/ (Cell Stem Cell)
  • The Long-Term Effects of Heated Tobacco Product Exposure on the Central Nervous System in a Mouse Model of Prodromal Alzheimer’s Disease https://www.stemcellsciencenews.com/newsletter/219054/ (Scientific Reports)
  • Synaptic-Like Transmission between Neural Axons and Arteriolar Smooth Muscle Cells Drives Cerebral Neurovascular Coupling https://www.stemcellsciencenews.com/newsletter/219229/ (Nature Neuroscience)
  • Yap/Taz Activity Is Associated with Increased Expression of Phosphoglycerate Dehydrogenase That Supports Myoblast Proliferation https://www.stemcellsciencenews.com/newsletter/219228/ (Cell And Tissue Research)
  • Predicting Myosin Heavy Chain Isoform from Post-Dissection Fiber Length in Human Skeletal Muscle Fibers https://www.stemcellsciencenews.com/newsletter/219225/ (American Journal Of Physiology-Cell Physiology)
  • Microglia Enhance Post-Anesthesia Neuronal Activity by Shielding Inhibitory Synapses https://www.stemcellsciencenews.com/newsletter/219271/ (Nature Neuroscience)
  • Long and Short-Term Effect of mTOR Regulation on Cerebral Organoid Growth and Differentiations https://www.stemcellsciencenews.com/newsletter/219266/ (Tissue Engineering And Regenerative Medicine)
  • Neocortical Neurogenesis in Development and Evolution—Human-Specific Features https://www.stemcellsciencenews.com/newsletter/219377/ (Journal of Comparative Neurology)
  • Apically Localized PANX1 Impacts Neuroepithelial Expansion in Human Cerebral Organoids https://www.stemcellsciencenews.com/newsletter/219468/ (Cell Death Discovery)
  • First Brain Organoids Grown from Fetal Tissue Offer Window on Development https://www.stemcellsciencenews.com/newsletter/219523/ (Science)
  • Molecular Profiling of Human Substantia Nigra Identifies Diverse Neuron Types Associated with Vulnerability in Parkinson’s Disease https://www.stemcellsciencenews.com/newsletter/219671/ (Science Advances)
  • IFITM3 Promotes Glioblastoma Stem Cell-Mediated Angiogenesis via Regulating JAK/STAT3/bFGF Signaling Pathway https://www.stemcellsciencenews.com/newsletter/219772/ (Cell Death & Disease)
  • Neural Stem Cell Homeostasis Is Affected in Cortical Organoids Carrying a Mutation in Angiogenin https://www.stemcellsciencenews.com/newsletter/219773/ (Journal Of Pathology)
  • The Role of IL-6 in Neurodegenerative Disorders https://www.stemcellsciencenews.com/newsletter/219840/ (Neurochemical Research)
  • TREM2 Variants That Cause Early Dementia and Increase Alzheimer’s Disease Risk Affect Gene Splicing https://www.stemcellsciencenews.com/newsletter/219838/ (Brain)
  • DNA Methylation-Mediated Repression of microRNA-410 Promotes the Growth of Human Glioma Cells and Triggers Cell Apoptosis Through Its Interaction with STAT3 https://www.stemcellsciencenews.com/newsletter/219919/ (Scientific Reports)
  • SARS-CoV-2 Infection Causes Dopaminergic Neuron Senescence https://www.stemcellsciencenews.com/newsletter/220096/ (Cell Stem Cell)
  • Modeling the Neuroimmune System in Alzheimer’s and Parkinson’s Diseases https://www.stemcellsciencenews.com/newsletter/220168/ (Journal of Neuroinflammation)

Organoid

  • Vascularized Liver-on-a-Chip Model to Investigate Nicotine-Induced Dysfunction https://www.stemcellsciencenews.com/newsletter/219017/ (Biomicrofluidics)
  • Human Apical-Out Nasal Organoids Reveal an Essential Role of Matrix Metalloproteinases in Airway Epithelial Differentiation https://www.stemcellsciencenews.com/newsletter/219027/ (Nature Communications)
  • High-Throughput Deconvolution of 3D Organoid Dynamics at Cellular Resolution for Cancer Pharmacology with Cellos https://www.stemcellsciencenews.com/newsletter/219116/ (Nature Communications)
  • Analysis of Off-Tumor Toxicities of T Cell-Engaging Bispecific Antibodies via Donor-Matched Intestinal Organoids and Tumoroids https://www.stemcellsciencenews.com/newsletter/219115/ (Nature Biomedical Engineering)
  • Kidney Organoid Models Reveal Cilium-Autophagy Metabolic Axis as a Therapeutic Target for PKD Both In Vitro and In Vivo https://www.stemcellsciencenews.com/newsletter/219113/ (Cell Stem Cell)
  • Spatiotemporal Modulation of Growth Factors Directs the Generation of Multilineage Mouse Embryonic Stem Cell-Derived Mammary Organoids https://www.stemcellsciencenews.com/newsletter/219112/ (Developmental Cell)
  • EGFR-Activated Myofibroblasts Promote Metastasis of Pancreatic Cancer https://www.stemcellsciencenews.com/newsletter/219111/ (Cancer Cell)
  • Predictive Metabolomic Signatures for Safety Assessment of Three Plastic Nanoparticles Using Intestinal Organoids https://www.stemcellsciencenews.com/newsletter/219187/ (Science Of The Total Environment)
  • Human Fetal Brain Self-Organizes Into Long-Term Expanding Organoids https://www.stemcellsciencenews.com/newsletter/219253/ (Cell)
  • Long and Short-Term Effect of mTOR Regulation on Cerebral Organoid Growth and Differentiations https://www.stemcellsciencenews.com/newsletter/219266/ (Tissue Engineering And Regenerative Medicine)
  • A Disulfidptosis-Related lncRNAs Signature in Hepatocellular Carcinoma: Prognostic Prediction, Tumor Immune Microenvironment and Drug Susceptibility https://www.stemcellsciencenews.com/newsletter/219320/ (Scientific Reports)
  • Human Conjunctiva Organoids To Study Ocular Surface Homeostasis and Disease https://www.stemcellsciencenews.com/newsletter/219475/ (Cell Stem Cell)
  • Stem Cell Investigations to Improve Cancer Treatment Among Payloads Flying on Axiom Space’s Third Private Astronaut Mission https://www.stemcellsciencenews.com/newsletter/219474/ (ISS National Laboratory)
  • Organoids Derived From Patients Provide a New Opportunity for Research and Individualized Treatment of Malignant Peritoneal Mesothelioma https://www.stemcellsciencenews.com/newsletter/219471/ (Molecular Cancer)
  • In Vitro Models for Investigating Intestinal Host-Pathogen Interactions https://www.stemcellsciencenews.com/newsletter/219472/ (Advanced Science)
  • Uniform Cerebral Organoid Culture on a Pillar Plate by Simple and Reproducible Spheroid Transfer From an Ultralow Attachment Well Plate https://www.stemcellsciencenews.com/newsletter/219470/ (Biofabrication)
  • Precancerous Nature of Intestinal Metaplasia With Increased Chance of Conversion and Accelerated DNA Methylation https://www.stemcellsciencenews.com/newsletter/219469/ (Gut)
  • Micro instrumentation for Brain Organoids https://www.stemcellsciencenews.com/newsletter/219647/ (Advanced Healthcare Materials)
  • Bioassembly of Multicellular Spheroids to Mimic Complex Tissue Structure Using Surface-Modified Magnetized Nanofibers https://www.stemcellsciencenews.com/newsletter/219689/ (Biofabrication)
  • Gelatin-Based Hybrid Hydrogels as Matrices for Organoid Culture https://www.stemcellsciencenews.com/newsletter/219889/ (Biomacromolecules)
  • Establishment of Tumor Microenvironment-Preserving Organoid Model from Patients with Intracranial Meningioma https://www.stemcellsciencenews.com/newsletter/220164/ (Cancer Cell International)

 

December 2023

Neural News

Organoid News

 

ESC & iPSC

November 2023

ESC & iPSC News

  • Metabolic Plasticity Sustains the Robustness of Caenorhabditis elegans Embryogenesis (EMBO Reports) https://www.stemcellsciencenews.com/newsletter/216547/
  • The PERK Branch of the Unfolded Protein Response Safeguards Protein Homeostasis and Mesendoderm Specification of Human Pluripotent Stem Cells (Advanced Science) https://www.stemcellsciencenews.com/newsletter/216809/
  • A Novel Perfusion Bioreactor Promotes the Expansion of Pluripotent Stem Cells in a 3D-Bioprinted Tissue Chamber (Biofabrication) https://www.stemcellsciencenews.com/newsletter/216803/
  • NR5A2 Connects Zygotic Genome Activation to the First Lineage Segregation in Totipotent Embryo(Cell Research) https://www.stemcellsciencenews.com/newsletter/217008/
  • Generation of Glucocorticoid-Producing Cells Derived from Human Pluripotent Stem Cells (Cell Reports Methods) https://www.stemcellsciencenews.com/newsletter/217006/
  • Mammalian Oocytes Store Proteins for the Early Embryo on Cytoplasmic Lattices (Cell) https://www.stemcellsciencenews.com/newsletter/217003/
  • Generation, Characterization, and Differentiation of Induced Pluripotent Stem-Like Cells in the Domestic Cat (Reproduction & Development) https://www.stemcellsciencenews.com/newsletter/217088/
  • Small Molecule-Mediated Reprogramming of Xenopus Blastula Stem Cells to a Neural Crest State (Developmental Biology) https://www.stemcellsciencenews.com/newsletter/217085/
  • This Hybrid Baby Monkey Is Made of Cells from Two Embryos (Nature) https://www.stemcellsciencenews.com/newsletter/217226/
  • Single-Cell, Whole-Embryo Phenotyping of Mammalian Developmental Disorders (Nature) https://www.stemcellsciencenews.com/newsletter/217353/
  • Generation of Induced Pluripotent Stem Cell Lines IRMBi003-A and IRMBi003-B from a Healthy Donor to Model Alzheimer’s Disease (Stem Cell Research) https://www.stemcellsciencenews.com/newsletter/217745/
  • Generation of an NCS1 Gene Knockout Human Induced Pluripotent Stem Cell Line Using CRISPR/Cas9 (Stem Cell Research) https://www.stemcellsciencenews.com/newsletter/217746/
  • Use of 2D Minilungs from Human Embryonic Stem Cells to Study the Interaction of Cryptococcus neoformans with the Respiratory Tract (Microbes And Infection) https://www.stemcellsciencenews.com/newsletter/218128/
  • Functional Engineering of Human iPSC-Derived Parasympathetic Neurons Enhances Responsiveness to Gastrointestinal Hormones (FEBS Open Bio) https://www.stemcellsciencenews.com/newsletter/218127/
  • Generation of Induced Pluripotent Stem Cell Line (RCMGi012-a) From Fibroblasts of Patient With Mucopolysaccharidosis Type VI (Stem Cell Research) https://www.stemcellsciencenews.com/newsletter/218126/

Cell Therapy News

  • CAR T Cell Design-Dependent Remodeling of the Brain Tumor-Immune Microenvironment Modulates Tumor-Associated Macrophages and Anti-Glioma Activity (Cancer Research Communications) https://www.stemcellsciencenews.com/newsletter/217570/
  • Implications of High Tumor Burden on Chimeric Antigen Receptor T Cell Immunotherapy (JAMA Oncology) https://www.stemcellsciencenews.com/newsletter/217588/
  • Anti-TACI Single and Dual-Targeting CAR T Cells Overcome BCMA Antigen Loss in Multiple Myeloma (Nature Communications) https://www.stemcellsciencenews.com/newsletter/217569/
  • CAR T Cells for Treating Autoimmune Diseases (RMD Open) https://www.stemcellsciencenews.com/newsletter/218023/
  • Cell-Based Therapy by Autologous Bone Marrow-Derived Mononuclear Cells for Bone Augmentation of Plate-Stabilized Proximal Humeral Fractures – a Multicentric, Randomized, Open Phase IIa Study (Stem Cells Translational Medicine) https://www.stemcellsciencenews.com/newsletter/218019/
  • Genetic Retargeting of E3 Ligases to Enhance CAR T Cell Therapy (Cell Chemical Biology) https://www.stemcellsciencenews.com/newsletter/218018/
  • An In Vitro Model of the Macrophage-Endothelial Interface to Characterize CAR T-cell Induced Cytokine Storm (Scientific Reports) https://www.stemcellsciencenews.com/newsletter/216840/
  • Smart Nanoparticles for Cancer Therapy (Signal Transduction and Targeted Therapy) https://www.stemcellsciencenews.com/newsletter/216992/
  • AT7867 Promotes Pancreatic Progenitor Differentiation of Human iPSCs (Stem Cell Reports) https://www.stemcellsciencenews.com/newsletter/216989/
  • Transplanting Old Organs Promotes Senescence in Young Recipients (American Journal Of Transplantation) https://www.stemcellsciencenews.com/newsletter/216988/
  • Injectable Supramolecular Hydrogels for In Situ Programming of CAR-T Cells towards Solid Tumor Immunotherapy (Advanced Materials) https://www.stemcellsciencenews.com/newsletter/217350/

Neural Cell News

  • iPS-Cell-Derived Microglia Promote Brain Organoid Maturation via Cholesterol Transfer (Nature) https://www.stemcellsciencenews.com/newsletter/216764/
  • Neuronal TIMP2 Regulates Hippocampus-Dependent Plasticity and Extracellular Matrix Complexity (Molecular Psychiatry) https://www.stemcellsciencenews.com/newsletter/216828/
  • A Purkinje Cell to Parabrachial Nucleus Pathway Enables Broad Cerebellar Influence over the Forebrain (Nature Neuroscience) https://www.stemcellsciencenews.com/newsletter/216884/
  • A Neurodegeneration Checkpoint Mediated by REST Protects against the Onset of Alzheimer’s Disease (Nature Communications) https://www.stemcellsciencenews.com/newsletter/216883/
  • A Spinal Cord Neuroprosthesis for Locomotor Deficits Due to Parkinson’s Disease (Nature Medicine) https://www.stemcellsciencenews.com/newsletter/216959/
  • Selective Plasticity of Fast and Slow Excitatory Synapses on Somatostatin Interneurons in Adult Visual Cortex (Nature Communications) https://www.stemcellsciencenews.com/newsletter/217048/
  • Peptide-Based Approaches to Directly Target Alpha-Synuclein in Parkinson’s Disease (Molecular Neurodegeneration) https://www.stemcellsciencenews.com/newsletter/217202/
  • STING Signaling in the Brain: Molecular Threats, Signaling Activities, and Therapeutic Challenges (Neuron) https://www.stemcellsciencenews.com/newsletter/217203/
  • Chemogenetic Approaches Reveal Dual Functions of Microglia in Seizures (Brain Behavior And Immunity) https://www.stemcellsciencenews.com/newsletter/217199/
  • The Circadian Clock Time Tunes Axonal Regeneration (Cell Metabolism) https://www.stemcellsciencenews.com/newsletter/217272/
  • Targeted Suppression of mTORC2 Reduces Seizures across Models of Epilepsy (Nature Communications) https://www.stemcellsciencenews.com/newsletter/217307/
  • Knockout or Inhibition of USP30 Protects Dopaminergic Neurons in a Parkinson’s Disease Mouse Model (Nature Communications) https://www.stemcellsciencenews.com/newsletter/217305/
  • Altered Corollary Discharge Signaling in the Auditory Cortex of a Mouse Model of Schizophrenia Predisposition (Nature Communications) https://www.stemcellsciencenews.com/newsletter/217399/
  • Molecular Biomarkers for Vascular Cognitive Impairment and Dementia (Nature Reviews Neurology) https://www.stemcellsciencenews.com/newsletter/217469/
  • Mitigating Aberrant Cdk5 Activation Alleviates Mitochondrial Defects and Motor Neuron Disease Symptoms in Spinal Muscular Atrophy (Proceedings Of The National Academy Of Sciences Of The United States Of America) https://www.stemcellsciencenews.com/newsletter/217558/
  • Characterization of Neuromuscular Transmission and Projections of Muscle Motor Neurons in the Rat Stomach (American Journal Of Physiology-Gastrointestinal And Liver Physiology) https://www.stemcellsciencenews.com/newsletter/217662/
  • Asteroid Impact: The Potential of Astrocytes to Modulate Human Neural Networks within Organoids (Frontiers In Neuroscience) https://www.stemcellsciencenews.com/newsletter/217763/
  • Sequential Appetite Suppression by Oral and Visceral Feedback to the Brainstem (Nature) https://www.stemcellsciencenews.com/newsletter/217762/
  • Third-Generation Rabies Viral Vectors Allow Nontoxic Retrograde Targeting of Projection Neurons with Greatly Increased Efficiency (Cell Reports Methods) https://www.stemcellsciencenews.com/newsletter/218092/
  • Disruption of the Autism Gene and Chromatin Regulator KDM5A Alters Hippocampal Cell Identity (Science Advances) https://www.stemcellsciencenews.com/newsletter/218132/

Organoid Cell News

  • The Drug Efficacy Testing in 3D Cultures Platform Identifies Effective Drugs for Ovarian Cancer Patients (NPJ Precision Oncology) https://www.stemcellsciencenews.com/newsletter/216766/
  • Using Picoliter Droplet Deposition to Track Clonal Competition in Adherent and Organoid Cancer Cell Cultures (Scientific Reports) https://www.stemcellsciencenews.com/newsletter/216765/
  • Cancer-on-Chip Models for Metastasis: Importance of the Tumor Microenvironment (Trends In Biotechnology) https://www.stemcellsciencenews.com/newsletter/216829/
  • SARS-CoV-2 Infection Engenders Heterogeneous Ribonucleoprotein Interactions to Impede Translation Elongation in the Lungs (Experimental & Molecular Medicine) https://www.stemcellsciencenews.com/newsletter/216841/
  • In-Organoid Single-Cell CRISPR Screening Reveals Determinants of Hepatocyte Differentiation and Maturation (Genome Biology) https://www.stemcellsciencenews.com/newsletter/217081/
  • Potential Application of Intestinal Organoids in Intestinal Diseases (Stem Cell Reviews and Reports) https://www.stemcellsciencenews.com/newsletter/217179/
  • Ascorbate Protects Human Kidney Organoids From Damage Induced by Cell-Free Hemoglobin (Disease Models & Mechanisms) https://www.stemcellsciencenews.com/newsletter/217178/
  • Hepatitis C Virus Infects and Perturbs Liver Stem Cells (mBio) https://www.stemcellsciencenews.com/newsletter/217177/
  • Patient-Derived Organoids Identify Tailored Therapeutic Options and Determinants of Plasticity in Sarcomatoid Urothelial Bladder Cancer (npj Precision Oncology) https://www.stemcellsciencenews.com/newsletter/217175/
  • Reconstruction of Dynamic Mammary Mini Gland In Vitro for Normal Physiology and Oncogenesis (Nature Methods) https://www.stemcellsciencenews.com/newsletter/217171/
  • Human Intestinal Organoids From Cronkhite-Canada Syndrome Patients Reveal Link Between Serotonin and Proliferation (Journal Of Clinical Investigation) https://www.stemcellsciencenews.com/newsletter/217172/
  • Cochlear Organoids Reveal Transcriptional Programs of Postnatal Hair Cell Differentiation from Supporting Cells (Cell Reports) https://www.stemcellsciencenews.com/newsletter/217311/
  • Modular 3D Printed Platform for Fluidically Connected Human Brain Organoid Culture (Biofabrication) https://www.stemcellsciencenews.com/newsletter/217310/
  • Recent Advances in Lung Organoid Development and Applications in Disease Modeling (Journal Of Clinical Investigation) https://www.stemcellsciencenews.com/newsletter/217398/
  • Single-Cell Transcriptomics Stratifies Organoid Models of Metabolic Dysfunction-Associated Steatotic Liver Disease (EMBO Journal) https://www.stemcellsciencenews.com/newsletter/217395/
  • Human Intestinal Organoids: Modeling Gastrointestinal Physiology and Immunopathology – Current Applications and Limitations (European Journal Of Immunology) https://www.stemcellsciencenews.com/newsletter/217496/
  • Stress-Free Cell Aggregation by Using the CEPT Cocktail Enhances Embryoid Body and Organoid Fitness (Biofabrication) https://www.stemcellsciencenews.com/newsletter/217605/
  • Engineered Synthetic Matrices for Human Intestinal Organoid Culture And Therapeutic Delivery (Advanced Materials) https://www.stemcellsciencenews.com/newsletter/217768/
  • Deriving Early Single-Rosette Brain Organoids from Human Pluripotent Stem Cells (Stem Cell Reports) https://www.stemcellsciencenews.com/newsletter/217766/
  • NOTCH3 Signaling Controls Human Trophoblast Stem Cell Expansion and Differentiation (Development) https://www.stemcellsciencenews.com/newsletter/217797/
  • Multi-Chamber Cardioids Unravel Human Heart Development and Cardiac Defects (Cell) https://www.stemcellsciencenews.com/newsletter/218150/

October 2023

Cell Therapy News

Neural News

Organoid News

 

September 2023

 

August 2023

 

July 2023

June 2023

 

 

May 2023

 

April 2023

 

March 2023

 

February 2023

 

January 2023

 

December 2022

·      RNA Degradation Eliminates Developmental Transcripts during Murine Embryonic Stem Cell Differentiation via CAPRIN1-XRN2 https://www.cell.com/developmental-cell/fulltext/S1534-5807(22)00814-0

·      Embryonic Origins of Adult Pluripotent Stem Cells https://www.cell.com/cell/fulltext/S0092-8674(22)01420-9

·      Bulk RNA sequencing analysis of developing human induced pluripotent cell-derived retinal organoids https://www.nature.com/articles/s41597-022-01853-x

·      Effect of thymoquinone on pharmacokinetics of 5-fluorouracil in rats and its effect on human cell line in vitro https://journals.sagepub.com/doi/10.1177/09603271211021475?icid=int.sj-full-text.similar-articles.1

·      Stress-Induced Reversible Cell-Cycle Arrest Requires PRC2/PRC1-Mediated Control of Mitophagy in Drosophila Germline Stem Cells and Human iPSCs https://www.cell.com/stem-cell-reports/fulltext/S2213-6711(22)00537-9

·      Plpp3, a novel regulator of pluripotency exit and endodermal differentiation of mouse embryonic stem cells https://journals.biologists.com/bio/article/12/1/bio059665/286423/Plpp3-a-novel-regulator-of-pluripotency-exit-and

·      Optimization of the proliferation and persistency of CAR T cells derived from human induced pluripotent stem cells https://www.nature.com/articles/s41551-022-00969-0

·      CD34dim cells identified as pluripotent stem cell-derived definitive hemogenic endothelium purified using bone morphogenetic protein 4 https://onlinelibrary.wiley.com/doi/full/10.1111/cpr.13366

·      A Reference Human Induced Pluripotent Stem Cell Line for Large-Scale Collaborative Studies https://www.nature.com/articles/s41467-022-35180-x

·      The Consequences of Recurrent Genetic and Epigenetic Variants in Human Pluripotent Stem Cells https://www.cell.com/cell-stem-cell/fulltext/S1934-5909(22)00453-2

·      Dialysis based-culture medium conditioning improved the generation of human induced pluripotent stem cell derived-liver organoid in a high cell density https://www.nature.com/articles/s41598-022-25325-9

 

November 2022

 

October 2022

World’s first stem cell treatment for spina bifida delivered during fetal surgery! https://health.ucdavis.edu/news/headlines/worlds-first-stem-cell-treatment-for-spina-bifida-delivered-during-fetal-surgery--/2022/10  https://ucdavis.app.box.com/s/bkou2xl5uwqee2rsc2zycjshgl98v1c5/file/1032501468464 

  • Identification of Stable Housekeeping Genes for Induced Pluripotent Stem Cells and -Derived Endothelial Cells for Drug Testing (Scientific Reports) https://www.nature.com/articles/s41598-022-20435-w
  • TGFβ Superfamily Signaling Regulates the State of Human Stem Cell Pluripotency and Capacity to Create Well-Structured Telencephalic Organoids (Stem Cell Reports) https://www.cell.com/stem-cell-reports/fulltext/S2213-6711(22)00422-2
  • The Kleisin Subunits of Cohesin Are Involved in the Fate Determination of Embryonic Stem Cells (Molecules and Cells) https://www.molcells.org/journal/view.html?doi=10.14348/molcells.2022.2042
  • Human Cellular Models for Retinal Disease: From Induced Pluripotent Stem Cells to Organoids (Retina-the Journal of Retinal and Vitreous Diseases) https://journals.lww.com/retinajournal/Abstract/2022/10000/HUMAN_CELLULAR_MODELS_FOR_RETINAL_DISEASE__From.1.aspx
  • Super-Enhancers Conserved within Placental Mammals Maintain Stem Cell Pluripotency (Proceedings of the National Academy of Sciences of the United States of America) https://www.pnas.org/doi/10.1073/pnas.2204716119
  • High Glucose Impairs Osteogenic Differentiation of Embryonic Stem Cells via Early Diversion of Beta-Catenin from Forkhead Box O to T Cell Factor Interaction (Birth Defects Research) https://onlinelibrary.wiley.com/doi/10.1002/bdr2.2085

 

September 2022

  • Retinoic Acid Delays Initial Photoreceptor Differentiation and Results in a Highly Structured Mature Retinal Organoid (Stem Cell Research & Therapy) https://stemcellres.biomedcentral.com/articles/10.1186/s13287-022-03146-x
  • Engineering Placenta-Like Organoids Containing Endogenous Vascular Cells from Human-Induced Pluripotent Stem Cells (Bioengineering & Translational Medicine) https://aiche.onlinelibrary.wiley.com/doi/full/10.1002/btm2.10390
  • Induction of Functional Xeno-Free MSCs from Human iPSCs via a Neural Crest Cell Lineage (NPJ Regenerative Medicine) https://www.nature.com/articles/s41536-022-00241-8
  • CTCF Acetylation at Lysine 20 Is Required for the Early Cardiac Mesoderm Differentiation of Embryonic Stem Cells (Cell Regeneration) https://cellregeneration.springeropen.com/articles/10.1186/s13619-022-00131-w
  • Evolutionary Origin of Vertebrate OCT4/POU5 Functions in Supporting Pluripotency (Nature Communications) https://www.nature.com/articles/s41467-022-32481-z
  • Dominant Role of DNA Methylation over H3K9me3 for IAP Silencing in Endoderm (Nature Communications) https://www.nature.com/articles/s41467-022-32978-7
  • LncRNA-Smad7 Mediates Cross-Talk between Nodal/TGF-β and BMP Signaling to Regulate Cell Fate Determination of Pluripotent and Multipotent Cells (Nucleic Acids Research) https://academic.oup.com/nar/advance-article/doi/10.1093/nar/gkac780/6711145
  • Passage Number Affects Differentiation of Sensory Neurons from Human Induced Pluripotent Stem Cells (Scientific Reports) https://www.nature.com/articles/s41598-022-19018-6
  • Modeling Urea Cycle Disorders Using iPSCs (NPJ Regenerative Medicine) https://www.nature.com/articles/s41536-022-00252-5
  • Building In Vitro Models of the Brain To Understand the Role of APOE in Alzheimer’s Disease [Life Science Alliance] https://www.life-science-alliance.org/content/5/11/e202201542
  • PFOS Disrupts Key Developmental Pathways during hiPSC Derived Cardiomyocyte Differentiation (In Vitro Toxicology in Vitro) https://www.sciencedirect.com/science/article/pii/S0887233322001734?via%3Dihub
  • Imprinting Fidelity in Mouse iPSCs Depends on Sex of Donor Cell and Medium Formulation (Nature Communications) https://www.nature.com/articles/s41467-022-33013-55
  • CRISPR-Cas9 Screen in Human Embryonic Stem Cells to Identify Genes Required for Neural Differentiation (STAR Protocols) https://www.sciencedirect.com/science/article/pii/S2666166722005627?via%3Dihub
  • Different Transcriptional Profiles of Human Embryonic Stem Cells Grown in a Feeder-Free Culture System and on Human Foreskin Fibroblast Feeder Layers (Aging-Us) https://www.aging-us.com/article/204282/text
  • Fast Generation of Forebrain Oligodendrocyte Spheroids from Human Embryonic Stem Cells by Transcription Factors (iScience) https://www.cell.com/action/showPdf?pii=S2589-0042%2822%2901444-4
  • METTLing in Stem Cell and Cancer Biology (Stem Cell Reviews and Reports) https://link.springer.com/article/10.1007/s12015-022-10444-7
  • A Stem Cell Roadmap of Ribosome Heterogeneity Reveals a Function for RPL10A in Mesoderm Production (Nature Communications) https://www.nature.com/articles/s41467-022-33263-3
  • Human PSCs Determine the Competency of Cerebral Organoid Differentiation via FGF Signaling and Epigenetic Mechanisms (iScience) https://www.cell.com/action/showPdf?pii=S2589-0042%2822%2901412-2
  • Mouse Embryo Model Derived Exclusively from Embryonic Stem Cells Undergoes Neurulation and Heart Development (Cell Stem Cell) https://www.cell.com/cell-stem-cell/fulltext/S1934-5909(22)00377-0
  • Heparinized Gelatin-Based Hydrogels for Differentiation of Induced Pluripotent Stem Cells (Biomacromolecules) https://pubs.acs.org/doi/10.1021/acs.biomac.2c00585
  • Acquisition and Maintenance of Pluripotency Are Influenced by Fibroblast Growth Factor, Leukemia Inhibitory Factor, and 2i in Bovine-Induced Pluripotent Stem Cells (Frontiers in Cell and Developmental Biology) https://www.stemcellsciencenews.com/newsletter/194131/
  • Recent Advances for Using Human Induced-Pluripotent Stem Cells as Pain-in-a-Dish Models of Neuropathic Pain (Experimental Neurology) https://www.sciencedirect.com/science/article/pii/S0014488622002485?via%3Dihub
  • Modeling Metabolic Diseases and Drug Response Using Stem Cells and Organoids (Nature Reviews Endocrinology) https://www.nature.com/articles/s41574-022-00733-z
  • Harnessing Conserved Signaling and Metabolic Pathways to Enhance the Maturation of Functional Engineered Tissues (NPJ Regenerative Medicine) https://www.nature.com/articles/s41536-022-00246-3
  • Spatial Molecular Anatomy of Germ Layers in the Gastrulating Cynomolgus Monkey Embryo (Cell Reports) https://www.cell.com/cell-reports/fulltext/S2211-1247(22)01105-6
  • Modeling Human Extraembryonic Mesoderm Cells Using Naive Pluripotent Stem Cells (Cell Stem Cell) https://www.cell.com/cell-stem-cell/fulltext/S1934-5909(22)00337-X
  • Systemic Proteomics and miRNA Profile Analysis of Exosomes Derived from Human Pluripotent Stem Cells (Stem Cell Research & Therapy) https://stemcellres.biomedcentral.com/articles/10.1186/s13287-022-03142-1
  • Robust Genome Editing via modRNA-Based Cas9 or Base Editor in Human Pluripotent Stem Cells (Cell Reports Methods) https://www.cell.com/cell-reports-methods/fulltext/S2667-2375(22)00172-2
  • Molecular Convergence between Down Syndrome and Fragile X Syndrome Identified Using Human Pluripotent Stem Cell Models (Cell Reports) https://www.cell.com/cell-reports/fulltext/S2211-1247(22)01136-6
  • Modeling Human Multi-Lineage Heart Field Development with Pluripotent Stem Cells (Cell Stem Cell) https://www.cell.com/cell-stem-cell/fulltext/S1934-5909(22)00343-5
  • Generation of Human Induced Pluripotential Stem Cells from Individuals with Complex Heterozygous, Isogenic Corrected, and Homozygous Bloc1s1 Mutations (Stem Cell Research) https://www.sciencedirect.com/science/article/pii/S1873506122002549

 

August 2022

  • DLL4 and VCAM1 Enhance the Emergence of T Cell–Competent Hematopoietic Progenitors from Human Pluripotent Stem Cells (Science Advances) https://www.science.org/doi/10.1126/sciadv.abn5522
  • Repeated Intravenous Administration of hiPSC-MSCs Enhance the Efficacy of Cell-Based Therapy in Tissue Regeneration (Communications Biology) https://www.nature.com/articles/s42003-022-03833-8