The University of Colorado, Boulder created the Grand Challenge to cultivate partnerships with government and industry to pursue solutions for pressing challenges facing our world today. The Integrated Remote and In Situ Sensing (IRISS) initiative is a pillar of the CU Boulder Grand Challenge and provides 4D measurement capabilities to study phenomena at a distance and from within. IRISS gathers data from the natural world using ground sensors, unmanned aircraft, spacecraft, and other sensor systems. This information can be used to reveal valuable insight about myriad events like climate fluctuations, drought conditions, and forest dieback.