Autonomous systems interact with human partners for extended periods of time, sometimes at remote distances and promise improved safety, reliability, efficiency, adaptability, resiliency, usability, affordability, and previously unattainable capabilities. Networked cyber-physical systems pervade modern society—From smart vehicles to medical robots, from automated infrastructure to teams of robotic explorers, from mobile devices to connected communities. The Autonomous Systems Interdisciplinary Research Theme (IRT) investigates how smart, safe, and secure autonomy can expand and exploit the full capabilities of these networked systems. This theme convenes faculty with expertise in robotics, cyber-security, verification and validation, control theory, artificial intelligence, unmanned systems, machine learning, formal methods, and human-robot interaction.