Chromosome segregation in the model and comparison to experiments

Chromosome biorientation modeling paper published in eLife

Feb. 13, 2020

Our paper " Mechanisms of chromosome biorientation and bipolar spindle assembly analyzed by computational modeling " was published in the Feb 13, 2020 edition of eLife today.

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Chromosome biorientation modeling paper posted to bioRxiv

June 5, 2019

Our paper "Mechanisms of chromosome biorientation and bipolar spindle assembly analyzed by computational modeling" was posted on the bioRxiv server.

Thumbnail figure for Edelmaier et al. 2019 Chromosome paper

Mechanisms of chromosome biorientation and bipolar spindle assembly analyzed by computational modeling

June 4, 2019

We develop a computational model of fission-yeast mitosis using a course-grained Brownian Dynamic framework in conjunction with a force-dependent kinetic Monte Carlo algorithm to replicate the biorientation and segregation of chromosomes.

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Cross-linker-mediated spindle assembly theory paper published in Biophysical Journal

May 7, 2019

Our paper " Theory of Cytoskeletal Reorganization during Cross-Linker-Mediated Mitotic Spindle Assembly " was published in the May 7, 2019 edition of Biophysical Journal. Our video was highlighted on the front page of the journal's website .

Model overview

Theory of cytoskeletal reorganization during crosslinker-mediated mitotic spindle assembly

May 7, 2019

We develop a torque-balance model that describes spindle assembly due to dynamic microtubule bundles, spindle-pole bodies, the nuclear envelope, and crosslinkers to predict spindle-assembly dynamics.

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Spindle assembly theory paper accepted by Biophysical Journal

March 6, 2019

Our paper "Theory of cytoskeletal reorganization during crosslinker-mediated mitotic spindle assembly" was accepted for publication at Biophysical Journal.

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Adam Lamson and Chris Edelmaier presented at the Rocky Mountain Yeast Meeting

Jan. 11, 2019

Adam Lamson and Chris Edelmaier presented their work on modeling mitotic spindle self-assembly at the Rocky Mountain Yeast Meeting held at Colorado State University.

Model overview

Spindle assembly theory paper posted on biorxiv

Sept. 22, 2018

Our paper "Theory of cytoskeletal reorganization during crosslinker-mediated mitotic spindle assembly" was posted on the biorxiv preprint server today.

Christopher Edelmaier photo

Christopher Edelmaier received ASCB travel grant

Sept. 20, 2018

Christopher Edelmaier received a travel grant from the American Society for Cell Biology to present at the ASCB-EMBo meeting. Congratulations!

Christopher Edelmaier, Nicolas Santander, Michael Stefferson, and Garrek Stemo graduated

May 10, 2018

Today the group celebrated four graduating students: Christopher Edelmaier (physics PhD), Nicolas Santander (engineering physics BS), Michael Stefferson (physics PhD) and Garrek Stemo (physics BA magna cum laude). Congratulations!

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