Publications

*indicates a trainee (postdoctoral fellow, graduate student, or an individual who went to graduate or medical school)

Inhibition of multiple staphylococcal growth states by a small molecule that disrupts membrane fluidity and voltage. *Dombach JL, *Christensen GL, *Allgood SC, Quintana JLJ, Detweiler CS.mSphere. 2024 Mar 26;9(3):e0077223. doi: 10.1128/msphere.00772-23.

Bacterial efflux pump modulators prevent bacterial growth in macrophages and under broth conditions that mimic the host environment.*Allgood SC, Su C-C, Crooks AL, *Meyer CT, Zhou B, Betterton MD, Barbachyn MR, Yu EW, Detweiler CS.mBio. 2023 Nov 3;14(6):e0249223. doi: 10.1128/mbio.02492-23.
 
Salmonella enterica Infections Are Disrupted by Two Small Molecules That Accumulate within Phagosomes and Differentially Damage Bacterial Inner Membranes.*Villanueva JA, Crooks AL, *Nagy TA, Quintana JLJ, Dalebroux ZD, Detweiler CS.mBio. 2022 Oct 26;13(5):e0179022. doi: 10.1128/mbio.01790-22.
 
A small molecule that disrupts S. Typhimurium membrane voltage without cell lysis reduces bacterial colonization of mice.Dombach JL, Quintana JL, Allgood SC, *Nagy TA, Gustafson DL, Detweiler CS.PLoS Pathog. 2022 Jun 10;18(6):e1010606. doi: 10.1371/journal.ppat.1010606.
 
Staphylococcal Bacterial Persister Cells, Biofilms, and Intracellular Infection Are Disrupted by JD1, a Membrane-Damaging Small Molecule. *Dombach JL, Quintana JLJ, Detweiler CS.mBio. 2021 Oct 26;12(5):e0180121. doi: 10.1128/mBio.01801-21.
 
An Oral Fluorouracil Prodrug, Capecitabine, Mitigates a Gram-Positive Systemic Infection in Mice.
*McLeod JR, Harvey PA, Detweiler CS.Microbiol Spectr. 2021 Sep 3;9(1):e0027521. doi: 10.1128/Spectrum.00275-21.
 
A small molecule that mitigates bacterial infection disrupts Gram-negative cell membranes and is inhibited by cholesterol and neutral lipids.*Dombach JL, Quintana JLJ, *Nagy TA, Wan C, Crooks AL, Yu H, Su CC, Yu EW, Shen J, Detweiler CS.PLoS Pathog. 2020 Dec 8;16(12):e1009119. doi: 10.1371/journal.ppat.1009119.
 
Clofazimine Reduces the Survival of Salmonella enterica in Macrophages and Mice.*Nagy TA, Crooks AL, Quintana JLJ, Detweiler CS.ACS Infect Dis. 2020 May 8;6(5):1238-1249. doi: 10.1021/acsinfecdis.0c00023.
 
Infection-based chemical screens uncover host-pathogen interactions.Detweiler CS.Curr Opin Microbiol. 2020 Apr;54:43-50. doi: 10.1016/j.mib.2019.12.003.
 
Salmonella enterica Requires Lipid Metabolism Genes To Replicate in Proinflammatory Macrophages and Mice. *Reens AL, *Nagy TA, Detweiler CS.Infect Immun. 2019 Dec 17;88(1):e00776-19. doi: 10.1128/IAI.00776-19.
 
Autophagy Induction by a Small Molecule Inhibits Salmonella Survival in Macrophages and Mice. *Nagy TA, Quintana JLJ, *Reens AL, Crooks AL, Detweiler CS.Antimicrob Agents Chemother. 2019 Sep 9;63(12):e01536-19. doi: 10.1128/AAC.01536-19.
 
Salmonella Typhimurium Infection of Human Monocyte-Derived Macrophages. Lathrop SK, Cooper KG, Binder KA, Starr T, Mampilli V, Detweiler CS, Steele-Mortimer O.Curr Protoc Microbiol. 2018 Aug;50(1):e56. doi: 10.1002/cpmc.56.
 
A cell-based infection assay identifies efflux pump modulators that reduce bacterial intracellular load.  *Reens AL, Crooks AL, Su CC, *Nagy TA, *Reens DL, *Podoll JD, *Edwards ME, Yu EW, Detweiler CS.PLoS Pathog. 2018 Jun 7;14(6):e1007115. doi: 10.1371/journal.ppat.1007115.

Potentiating antibiotics in drug-resistant clinical isolates via stimuli-activated superoxide generation. *Courtney CM, Goodman SM, *Nagy TA, Levy M, Bhusal P, Madinger NE, Detweiler CS, Nagpal P, Chatterjee A.Sci Adv. 2017 Oct 4;3(10):e1701776. doi: 10.1126/sciadv.1701776.

A New Way to Beat Intestinal Pathogens.Detweiler CS.Trends Microbiol. 2017 Mar;25(3):169-170. doi: 10.1016/j.tim.2017.01.003.
 
Salmonella Meningitis Associated with Monocyte Infiltration in Mice. *Bauler TJ, Starr T, *Nagy TA, Sridhar S, Scott D, Winkler CW, Steele-Mortimer O, Detweiler CS, Peterson KE.Am J Pathol. 2017 Jan;187(1):187-199. doi: 10.1016/j.ajpath.2016.09.002.

Long-term live-cell imaging reveals new roles for Salmonella effector proteins SseG and SteA. *McQuate SE, Young AM, *Silva-Herzog E, *Bunker E, Hernandez M, de Chaumont F, Liu X, Detweiler CS, Palmer AE.Cell Microbiol. 2017 Jan;19(1):10.1111/cmi.12641. doi: 10.1111/cmi.12641.

Physiologic Stresses Reveal a Salmonella Persister State and TA Family Toxins Modulate Tolerance to These Stresses. *Silva-Herzog E, *McDonald EM, Crooks AL, Detweiler CS.PLoS One. 2015 Dec 3;10(12):e0141343. doi: 10.1371/journal.pone.0141343.

Bacterial Stimulation of Toll-Like Receptor 4 Drives Macrophages To Hemophagocytose.*McDonald EM, *Pilonieta MC, *Nick HJ, Detweiler CS.Infect Immun. 2015 Oct 12;84(1):47-55. doi: 10.1128/IAI.01149-15

Increased ferroportin-1 expression and rapid splenic iron loss occur with anemia caused by Salmonella enterica Serovar Typhimurium infection in mice. Brown DE, *Nick HJ, *McCoy MW, *Moreland SM, Stepanek AM, Benik R, O'Connell KE, *Pilonieta MC, *Nagy TA, Detweiler CS.Infect Immun. 2015 Jun;83(6):2290-9. doi: 10.1128/IAI.02863-14.

The biomechanisms of metal and metal-oxide nanoparticles' interactions with cells.  *Teske SS, Detweiler CS.Int J Environ Res Public Health. 2015 Jan 22;12(2):1112-34. doi: 10.3390/ijerph120201112.

Salmonella enterica infection stimulates macrophages to hemophagocytose. *Pilonieta MC, *Moreland SM, *English CN, Detweiler CS.mBio. 2014 Dec 9;5(6):e02211. doi: 10.1128/mBio.02211-14.

Salmonella acquires ferrous iron from haemophagocytic macrophages.  *Nagy TA, *Moreland SM, Detweiler CS.Mol Microbiol. 2014 Sep;93(6):1314-26. doi: 10.1111/mmi.12739.

The ferric enterobactin transporter Fep is required for persistent Salmonella enterica serovar typhimurium infection.*Nagy TA, *Moreland SM, Andrews-Polymenis H, Detweiler CS.Infect Immun. 2013 Nov;81(11):4063-70. doi: 10.1128/IAI.00412-13.
 
Hemophagocytic macrophages in murine typhoid fever have an anti-inflammatory phenotype.
*McCoy MW, *Moreland SM, Detweiler CS.Infect Immun. 2012 Oct;80(10):3642-9. doi: 10.1128/IAI.00656-12. Epub 2012 Aug 6.
 
A glycine betaine importer limits Salmonella stress resistance and tissue colonization by reducing trehalose production.
*Pilonieta MC, *Nagy TA, *Jorgensen DR, Detweiler CS.Mol Microbiol. 2012 Apr;84(2):296-309. doi: 10.1111/j.1365-2958.2012.08022.x.
 
Salmonella enterica replication in hemophagocytic macrophages requires two type three secretion systems.
*Silva-Herzog E, Detweiler CS.Infect Immun. 2010 Aug;78(8):3369-77. doi: 10.1128/IAI.00292-10.
 
Chronic murine typhoid fever is a natural model of secondary hemophagocytic lymphohistiocytosis.
Brown DE, *McCoy MW, *Pilonieta MC, *Nix RN, Detweiler CS.PLoS One. 2010 Feb 26;5(2):e9441. doi: 10.1371/journal.pone.0009441.
 
A protein important for antimicrobial peptide resistance, YdeI/OmdA, is in the periplasm and interacts with OmpD/NmpC.
*Pilonieta MC, *Erickson KD, Ernst RK, Detweiler CS.J Bacteriol. 2009 Dec;191(23):7243-52. doi: 10.1128/JB.00688-09.
 
Intracellular microbes and haemophagocytosis.
*Silva-Herzog E, Detweiler CS.Cell Microbiol. 2008 Nov;10(11):2151-8. doi: 10.1111/j.1462-5822.2008.01192.x.
 
Hemophagocytic macrophages harbor Salmonella enterica during persistent infection.
*Nix RN, *Altschuler SE, Henson PM, Detweiler CS.PLoS Pathog. 2007 Dec;3(12):e193. doi: 10.1371/journal.ppat.0030193.
 
The Rcs phosphorelay system is specific to enteric pathogens/commensals and activates ydeI, a gene important for persistent Salmonella infection of mice.
*Erickson KD, Detweiler CS.Mol Microbiol. 2006 Nov;62(3):883-94. doi: 10.1111/j.1365-2958.2006.05420.x.