Publications

*indicates a trainee (postdoctoral fellow, graduate student, or an individual who went to graduate or medical school)

Inhibition of multiple staphylococcal growth states by a small molecule that disrupts membrane fluidity and voltage. *Dombach JL, *Christensen GL, *Allgood SC, Quintana JLJ, Detweiler CS. mSphere. 2024 Mar 26;9(3):e0077223. doi: 10.1128/msphere.00772-23.

Bacterial efflux pump modulators prevent bacterial growth in macrophages and under broth conditions that mimic the host environment. *Allgood SC, Su C-C, Crooks AL, *Meyer CT, Zhou B, Betterton MD, Barbachyn MR, Yu EW, Detweiler CS. mBio. 2023 Nov 3;14(6):e0249223. doi: 10.1128/mbio.02492-23.

A small molecule that disrupts S. Typhimurium membrane voltage without cell lysis reduces bacterial colonization of mice. Dombach JL, Quintana JL, Allgood SC, *Nagy TA, Gustafson DL, Detweiler CS. PLoS Pathog. 2022 Jun 10;18(6):e1010606. doi: 10.1371/journal.ppat.1010606.

*McLeod JR, Harvey PA, Detweiler CS. Microbiol Spectr. 2021 Sep 3;9(1):e0027521. doi: 10.1128/Spectrum.00275-21.

A small molecule that mitigates bacterial infection disrupts Gram-negative cell membranes and is inhibited by cholesterol and neutral lipids. *Dombach JL, Quintana JLJ, *Nagy TA, Wan C, Crooks AL, Yu H, Su CC, Yu EW, Shen J, Detweiler CS. PLoS Pathog. 2020 Dec 8;16(12):e1009119. doi: 10.1371/journal.ppat.1009119.

Clofazimine Reduces the Survival of Salmonella enterica in Macrophages and Mice. *Nagy TA, Crooks AL, Quintana JLJ, Detweiler CS. ACS Infect Dis. 2020 May 8;6(5):1238-1249. doi: 10.1021/acsinfecdis.0c00023.

Infection-based chemical screens uncover host-pathogen interactions. Detweiler CS. Curr Opin Microbiol. 2020 Apr;54:43-50. doi: 10.1016/j.mib.2019.12.003.

Autophagy Induction by a Small Molecule Inhibits Salmonella Survival in Macrophages and Mice. *Nagy TA, Quintana JLJ, *Reens AL, Crooks AL, Detweiler CS. Antimicrob Agents Chemother. 2019 Sep 9;63(12):e01536-19. doi: 10.1128/AAC.01536-19.

Salmonella Typhimurium Infection of Human Monocyte-Derived Macrophages. Lathrop SK, Cooper KG, Binder KA, Starr T, Mampilli V, Detweiler CS, Steele-Mortimer O. Curr Protoc Microbiol. 2018 Aug;50(1):e56. doi: 10.1002/cpmc.56.

A cell-based infection assay identifies efflux pump modulators that reduce bacterial intracellular load. *Reens AL, Crooks AL, Su CC, *Nagy TA, *Reens DL, *Podoll JD, *Edwards ME, Yu EW, Detweiler CS. PLoS Pathog. 2018 Jun 7;14(6):e1007115. doi: 10.1371/journal.ppat.1007115.

Potentiating antibiotics in drug-resistant clinical isolates via stimuli-activated superoxide generation. *Courtney CM, Goodman SM, *Nagy TA, Levy M, Bhusal P, Madinger NE, Detweiler CS, Nagpal P, Chatterjee A. Sci Adv. 2017 Oct 4;3(10):e1701776. doi: 10.1126/sciadv.1701776.

A New Way to Beat Intestinal Pathogens. Detweiler CS. Trends Microbiol. 2017 Mar;25(3):169-170. doi: 10.1016/j.tim.2017.01.003.

Salmonella Meningitis Associated with Monocyte Infiltration in Mice. *Bauler TJ, Starr T, *Nagy TA, Sridhar S, Scott D, Winkler CW, Steele-Mortimer O, Detweiler CS, Peterson KE. Am J Pathol. 2017 Jan;187(1):187-199. doi: 10.1016/j.ajpath.2016.09.002.

Long-term live-cell imaging reveals new roles for Salmonella effector proteins SseG and SteA. *McQuate SE, Young AM, *Silva-Herzog E, *Bunker E, Hernandez M, de Chaumont F, Liu X, Detweiler CS, Palmer AE. Cell Microbiol. 2017 Jan;19(1):10.1111/cmi.12641. doi: 10.1111/cmi.12641.

Physiologic Stresses Reveal a Salmonella Persister State and TA Family Toxins Modulate Tolerance to These Stresses. *Silva-Herzog E, *McDonald EM, Crooks AL, Detweiler CS. PLoS One. 2015 Dec 3;10(12):e0141343. doi: 10.1371/journal.pone.0141343.

Bacterial Stimulation of Toll-Like Receptor 4 Drives Macrophages To Hemophagocytose. *McDonald EM, *Pilonieta MC, *Nick HJ, Detweiler CS. Infect Immun. 2015 Oct 12;84(1):47-55. doi: 10.1128/IAI.01149-15

Increased ferroportin-1 expression and rapid splenic iron loss occur with anemia caused by Salmonella enterica Serovar Typhimurium infection in mice. Brown DE, *Nick HJ, *McCoy MW, *Moreland SM, Stepanek AM, Benik R, O'Connell KE, *Pilonieta MC, *Nagy TA, Detweiler CS. Infect Immun. 2015 Jun;83(6):2290-9. doi: 10.1128/IAI.02863-14.

The biomechanisms of metal and metal-oxide nanoparticles' interactions with cells. *Teske SS, Detweiler CS. Int J Environ Res Public Health. 2015 Jan 22;12(2):1112-34. doi: 10.3390/ijerph120201112.

Salmonella enterica infection stimulates macrophages to hemophagocytose. *Pilonieta MC, *Moreland SM, *English CN, Detweiler CS. mBio. 2014 Dec 9;5(6):e02211. doi: 10.1128/mBio.02211-14.

Salmonella acquires ferrous iron from haemophagocytic macrophages. *Nagy TA, *Moreland SM, Detweiler CS. Mol Microbiol. 2014 Sep;93(6):1314-26. doi: 10.1111/mmi.12739.

The ferric enterobactin transporter Fep is required for persistent Salmonella enterica serovar typhimurium infection. *Nagy TA, *Moreland SM, Andrews-Polymenis H, Detweiler CS. Infect Immun. 2013 Nov;81(11):4063-70. doi: 10.1128/IAI.00412-13.

*McCoy MW, *Moreland SM, Detweiler CS. Infect Immun. 2012 Oct;80(10):3642-9. doi: 10.1128/IAI.00656-12. Epub 2012 Aug 6.

*Pilonieta MC, *Nagy TA, *Jorgensen DR, Detweiler CS. Mol Microbiol. 2012 Apr;84(2):296-309. doi: 10.1111/j.1365-2958.2012.08022.x.

*Silva-Herzog E, Detweiler CS. Infect Immun. 2010 Aug;78(8):3369-77. doi: 10.1128/IAI.00292-10.

Brown DE, *McCoy MW, *Pilonieta MC, *Nix RN, Detweiler CS. PLoS One. 2010 Feb 26;5(2):e9441. doi: 10.1371/journal.pone.0009441.

*Pilonieta MC, *Erickson KD, Ernst RK, Detweiler CS. J Bacteriol. 2009 Dec;191(23):7243-52. doi: 10.1128/JB.00688-09.

*Silva-Herzog E, Detweiler CS. Cell Microbiol. 2008 Nov;10(11):2151-8. doi: 10.1111/j.1462-5822.2008.01192.x.

*Nix RN, *Altschuler SE, Henson PM, Detweiler CS. PLoS Pathog. 2007 Dec;3(12):e193. doi: 10.1371/journal.ppat.0030193.

*Erickson KD, Detweiler CS. Mol Microbiol. 2006 Nov;62(3):883-94. doi: 10.1111/j.1365-2958.2006.05420.x.

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