Institute for Behavioral Genetics
University of Colorado Boulder
447 UCB
Boulder, CO 80309-0447
Research Interests:
The use of genetic strategies to identify the underlying biological bases for the behavioral and physiological actions of drugs of abuse with special emphasis on nicotine.
Active Grants:
- NIDA U01DA043802 (Stitzel, JA, Radcliffe, RA) 4/1/18-12/31/22. Genetic modifiers of Chrna5 deletion in mice: role in nicotine behaviors modulated by the medial habenula-IPN pathway. Role: PI
- NIDA R01DA044283 (Vrieze, S). Deep sequencing, phenotyping, and imputation in large-scale biobanks: a novel and cost-effective framework to identify rare mutations associated with addiction. Role: Co-investigator
-
AB Nexus Grant (Stitzel, Patel MPI). Multi-generation impact of developmental nicotine exposure on mitochondrial function. Role: Lead PI
Additional Resources:
Molecular Neurogenetics Laboratory
Current lab
Former Trainees
Jennifer Wilking
Doctoral student
2005-2009
Sheila Maier
Masters student
2006-2008
Tristan McClure-Begley
Doctoral student
2008-2010
Janessa Jacobs
Masters student
2008-2010
William Horton
Doctoral student
2009-2013
Hunter Mathews
Doctoral student
2014-2020
Jordan Buck
Doctoral student
2016-2020
Amanda Alvarado
Masters student
2017-2019
Xiao Li
Postdoctoral trainee
2002-2003
Sharon Mexal
Postdoctoral trainee
2005-2007
Tom Precht
Postdoctoral trainee
2008-2010
Anne Tammamaki
Postdoctoral trainee
2009-2012
Cristian Zambrano
Postdoctoral trainee
2009-2012, 2015-2017
Andre Zalud
Postdoctoral trainee
2011-2014
Rebecca Helfand
Postdoctoral trainee
2011-2014
Peter Dobelis
Postdoctoral trainee
2015-2017
Heidi O'Neill
Postdoctoral trainee
2015-2019
EXAMANING THE ROLE OF THE D397N CHRNA5 NICOTINIC ACETYLCHOLINE POLYMORPHISM (RS16969989) ON ALCOHOL-RELATED BEHAVIORS IN MICE
Publication Date: 2016-06-25
Type: Conference Proceeding
Rare, low frequency and common coding variants in CHRNA5 and their contribution to nicotine dependence in European and African Americans
Olfson E; Saccone NL; Johnson EO; Chen L-S; Culverhouse R; Doheny K; Foltz SM; Fox L; Gogarten SM; Hartz S...
- Olfson E
- Saccone NL
- Johnson EO
- Chen L-S
- Culverhouse R
- Doheny K
- Foltz SM
- Fox L
- Gogarten SM
- Hartz S
Publication Date: 2016-05-01
Type: Journal Article
Nicotinic Acetylcholine Receptor Technologies
Publication Date: 2016-01-01
Type: Chapter
Using Natural Genetic Variability in Nicotinic Receptor Genes to Understand the Function of Nicotinic Receptors
Publication Date: 2016-01-01
Type: Chapter
Nicotinic acetylcholine receptors: upregulation, age-related effects and associations with drug use
Publication Date: 2016-01-01
Type: Journal Article
The β3 subunit of the nicotinic acetylcholine receptor: Modulation of gene expression and nicotine consumption
Publication Date: 2015-12-01
Type: Journal Article
A multiancestry study identifies novel genetic associations with CHRNA5 methylation in human brain and risk of nicotine dependence
Publication Date: 2015-10-15
Type: Journal Article
Natural genetic variability of the neuronal nicotinic acetylcholine receptor subunit genes in mice: Consequences and confounds
Publication Date: 2015-09-01
Type: Journal Article
Crucial role of nicotinic α5 subunit variants for Ca2+ fluxes in ventral midbrain neurons
Publication Date: 2015-08-01
Type: Journal Article
Melatonin administration alters nicotine preference consumption via signaling through high-affinity melatonin receptors
Publication Date: 2015-07-01
Type: Journal Article
Maximizing the effect of an alpha 7 nicotinic receptor PAM in a mouse model of schizophrenia-like sensory inhibition deficits
Publication Date: 2015-06-22
Type: Journal Article
Presynaptic GABA(B) autoreceptor regulation of nicotinic acetylcholine receptor mediated [H-3]-GABA release from mouse synaptosomes
Publication Date: 2014-09-01
Type: Journal Article
Long-term improvements in sensory inhibition with gestational choline supplementation linked to α7 nicotinic receptors through studies in Chrna7 null mutation mice
Publication Date: 2014-03-13
Type: Journal Article
Genetic Contributions of the alpha 5 Nicotinic Receptor Subunit to Smoking Behavior
Type: Chapter
Functional characterization of SNPs in CHRNA3/B4 intergenic region associated with drug behaviors
Publication Date: 2013-09-05
Type: Journal Article
BEHAVIORAL DISINHIBITION: SEQUENCING CHRN GENES IN A SELECTED SAMPLE TO IDENTIFY NOVEL VARIANTS
Ehringer MA; Kamens HM; Corley RP; Simonson M; Poole A; Richmond P; Stitzel JA; Dowell R; Krauter K; McQueen MB...
- Ehringer MA
- Kamens HM
- Corley RP
- Simonson M
- Poole A
- Richmond P
- Stitzel JA
- Dowell R
- Krauter K
- McQueen MB
Publication Date: 2013-06-01
Type: Journal Article
Alternative CHRNB4 3'-UTRs Mediate the Allelic Effects of SNP rs1948 on Gene Expression
Publication Date: 2013-05-14
Type: Journal Article
Diurnal variation in nicotine sensitivity in mice: Role of genetic background and melatonin
Publication Date: 2012-11-01
Type: Journal Article
Impact of human D398N single nucleotide polymorphism on intracellular calcium response mediated by alpha 3 beta 4 alpha 5 nicotinic acetylcholine receptors
Publication Date: 2012-11-01
Type: Journal Article
ROLE OF CHRN GENES IN ALCOHOL AND TOBACCO CO-MORBIDTY: HUMAN AND MOLECULAR GENETIC STUDIES
Publication Date: 2012-09-09
Type: Conference Proceeding
Increased Genetic Vulnerability to Smoking at CHRNA5 in Early-Onset Smokers
Hartz SM; Short SE; Saccone NL; Culverhouse R; Chen L; Schwantes-An T-H; Coon H; Han Y; Stephens SH; Sun J...
- Hartz SM
- Short SE
- Saccone NL
- Culverhouse R
- Chen L
- Schwantes-An T-H
- Coon H
- Han Y
- Stephens SH
- Sun J
Publication Date: 2012-08-01
Type: Journal Article
Comparison of nicotine oral consumption and baseline anxiety measures in adolescent and adult C57BL/6J and C3H/Ibg mice
Publication Date: 2012-08-01
Type: Journal Article
REDUCED Chrna7 EXPRESSION IN MICE IS ASSOCIATED WITH DECREASES IN HIPPOCAMPAL MARKERS OF INHIBITORY FUNCTION: IMPLICATIONS FOR NEUROPSYCHIATRIC DISEASES
Publication Date: 2012-04-05
Type: Journal Article
Rare missense variants in CHRNB4 are associated with reduced risk of nicotine dependence
Haller G; Druley T; Vallania FL; Mitra RD; Li P; Akk G; Steinbach JH; Breslau N; Johnson E; Hatsukami D...
- Haller G
- Druley T
- Vallania FL
- Mitra RD
- Li P
- Akk G
- Steinbach JH
- Breslau N
- Johnson E
- Hatsukami D
Publication Date: 2012-02-01
Type: Journal Article
Recent advances in gene manipulation and nicotinic acetylcholine receptor biology
Publication Date: 2011-10-15
Type: Journal Article
Pages
Recruiting
Dr. Stitzel is recruiting new students for a fall 2025 start date. Applications are typically due mid November; for exact dates please check the Department of Integrative Physiology website, if you intend to work with Dr. Stitzel. Additional information is available on IBG's Prospective Students page.
The Stitzel lab is not currently recruiting postdocs.